Golf -
PTH2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | K | 343 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | K | 343 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | L | 340 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | F | 269 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | F | 269 | - | G.S3 | V | 204 | G.S3.01 |
Polar | C-term | Y | 495 | - | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | C-term | Y | 495 | - | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | C-term | Y | 495 | - | G.S6 | P | 348 | G.S6.03 |
Polar | C-term | S | 498 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | C-term | S | 498 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | C-term | S | 498 | - | G.S6 | H | 349 | G.S6.04 |
Polar | TM6 | K | 360 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | K | 360 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | K | 360 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | Y | 495 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | C-term | Y | 495 | - | G.H4 | R | 329 | G.H4.12 |
Polar | TM2 | R | 176 | 2x46 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | A | 268 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | A | 268 | - | G.H5 | R | 367 | G.H5.12 |
Aromatic | TM2 | R | 176 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | R | 176 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | R | 176 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM5 | L | 340 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | K | 343 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Ionic | TM5 | E | 346 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Polar | TM5 | E | 346 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | E | 346 | 5x67 | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | K | 360 | 6x37 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 360 | 6x37 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | E | 257 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM3 | I | 265 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 265 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 265 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | L | 492 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Aromatic | ICL2 | F | 269 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 269 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 269 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | A | 268 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | A | 268 | - | G.H5 | I | 370 | G.H5.15 |
Polar | TM5 | K | 343 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | K | 343 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | K | 343 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | V | 367 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | Y | 495 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM3 | I | 265 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 265 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | L | 492 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | C-term | L | 492 | - | G.H4 | D | 330 | G.H4.13 |
Polar | C-term | H | 489 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | C-term | H | 489 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | C-term | H | 489 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | C-term | H | 489 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | C-term | W | 497 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | W | 497 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | C-term | P | 493 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | C-term | P | 493 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | C-term | P | 493 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL2 | F | 269 | - | G.H5 | R | 367 | G.H5.12 |
Polar | C-term | D | 487 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Van-der-waals | C-term | D | 487 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Van-der-waals | TM3 | Y | 260 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | T | 273 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | T | 273 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM5 | T | 347 | 5x68 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM5 | T | 347 | 5x68 | G.h4s6 | Y | 345 | G.h4s6.20 |
Ionic | TM5 | K | 343 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 343 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 343 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 343 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM3 | L | 264 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | L | 492 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | TM3 | L | 261 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | H | 489 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | C-term | H | 489 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Van-der-waals | C-term | H | 489 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | TM3 | L | 261 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 261 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM6 | K | 360 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 360 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 360 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | L | 368 | 6x45 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 492 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | C-term | L | 492 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | TM5 | L | 340 | 5x61 | G.H5 | L | 381 | G.H5.26 |
Polar | TM5 | T | 347 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | T | 347 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM7 | Y | 413 | 7x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM7 | Y | 413 | 7x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | V | 496 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | C-term | V | 496 | - | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | S | 364 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 364 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | S | 364 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | G | 494 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | C-term | G | 494 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM5 | I | 344 | 5x65 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM5 | I | 344 | 5x65 | G.H5 | L | 381 | G.H5.26 |
Aromatic | ICL2 | F | 269 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 269 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 269 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | C-term | Y | 495 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | C-term | Y | 495 | - | G.H4 | L | 333 | G.H4.16 |
Polar | H8 | G | 418 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | G | 418 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | V | 496 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | C-term | W | 497 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Polar | C-term | V | 496 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | ICL2 | F | 269 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 269 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM2 | H | 180 | 2x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | V | 496 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | C-term | V | 496 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM3 | L | 264 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | F | 269 | - | G.S3 | F | 206 | G.S3.03 |