G15 -
S1P3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | S | 224 | 5x67 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | N | 373 | - | G.H1 | S | 56 | G.H1.02 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 241 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM7 | Y | 298 | 7x53 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM7 | Y | 298 | 7x53 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | N | 149 | 34x56 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | N | 149 | 34x56 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | N | 149 | 34x56 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | R | 144 | 34x51 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | L | 371 | - | H.HA | L | 81 | H.HA.10 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | F | 376 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | F | 376 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | M | 365 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Van-der-waals | C-term | M | 365 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | Y | 146 | 34x53 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | Y | 146 | 34x53 | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | T | 244 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 244 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 244 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Ionic | TM6 | R | 237 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Polar | TM6 | R | 237 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | TM6 | R | 237 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | TM6 | R | 237 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | TM6 | R | 237 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 237 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | N | 149 | 34x56 | G.HN | L | 33 | G.HN.48 |
Hydrophobic | ICL2 | N | 149 | 34x56 | G.HN | L | 33 | G.HN.48 |
Van-der-waals | ICL2 | N | 149 | 34x56 | G.HN | L | 33 | G.HN.48 |
Polar | TM6 | N | 234 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | N | 234 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | N | 234 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | I | 375 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | I | 375 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | TM6 | R | 237 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | R | 237 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 237 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | G | 374 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | G | 374 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | C | 377 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | C | 377 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | C | 377 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | ICL2 | R | 144 | 34x51 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM5 | S | 225 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | S | 225 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | S | 225 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Polar | TM5 | S | 225 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | S | 225 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | C-term | Q | 372 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | Q | 372 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | N | 373 | - | G.H1 | I | 59 | G.H1.05 |
Van-der-waals | C-term | N | 373 | - | G.H1 | I | 59 | G.H1.05 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | V | 229 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | P | 145 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 145 | 34x52 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | G | 374 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | G | 374 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | ICL2 | P | 145 | 34x52 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | P | 145 | 34x52 | G.h2s4 | I | 227 | G.h2s4.05 |
Aromatic | C-term | F | 376 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | F | 376 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | F | 376 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | TM5 | K | 228 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | K | 228 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | K | 228 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | N | 373 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Van-der-waals | C-term | N | 373 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Hydrophobic | C-term | I | 375 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | TM5 | V | 222 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | N | 373 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | N | 373 | - | G.hfs2 | T | 189 | G.hfs2.05 |
Polar | ICL2 | M | 143 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | F | 376 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | F | 376 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM6 | A | 240 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | A | 240 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | C | 377 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | C | 377 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | C | 377 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | C | 363 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | C | 363 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Polar | C-term | N | 373 | - | G.H1 | K | 60 | G.H1.06 |
Hydrophobic | C-term | N | 373 | - | G.H1 | K | 60 | G.H1.06 |
Van-der-waals | C-term | N | 373 | - | G.H1 | K | 60 | G.H1.06 |
Van-der-waals | ICL2 | A | 148 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL3 | V | 229 | - | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM7 | A | 301 | 7x56 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM7 | A | 301 | 7x56 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM7 | A | 301 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | E | 304 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | E | 304 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | E | 304 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | S | 225 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 371 | - | H.HA | G | 77 | H.HA.06 |
Van-der-waals | C-term | L | 371 | - | H.HA | G | 77 | H.HA.06 |
Polar | C-term | N | 373 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | N | 373 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | TM2 | Y | 75 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM2 | Y | 75 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | Y | 75 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | T | 139 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | R | 144 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | R | 144 | 34x51 | G.HN | K | 37 | G.HN.52 |
Ionic | ICL2 | D | 147 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | D | 147 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | D | 147 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | D | 147 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | G | 374 | - | G.H1 | I | 59 | G.H1.05 |
Polar | C-term | C | 377 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | C | 377 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | C | 377 | - | G.S2 | C | 196 | G.S2.05 |
Polar | C-term | I | 375 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | I | 375 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL2 | P | 145 | 34x52 | G.H5 | R | 366 | G.H5.18 |
Polar | C-term | C | 377 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | C | 377 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | C | 377 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM4 | K | 150 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | K | 150 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | TM2 | R | 73 | 2x38 | G.H5 | E | 370 | G.H5.22 |
Ionic | ICL2 | D | 147 | 34x54 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | D | 147 | 34x54 | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | D | 147 | 34x54 | G.HN | K | 36 | G.HN.51 |
Polar | H8 | S | 302 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | S | 302 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | S | 302 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | M | 365 | - | H.HA | L | 81 | H.HA.10 |
Polar | C-term | Q | 372 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Van-der-waals | C-term | Q | 372 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | V | 229 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | A | 148 | 34x55 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | L | 371 | - | H.HA | F | 78 | H.HA.07 |
Van-der-waals | C-term | L | 371 | - | H.HA | F | 78 | H.HA.07 |
Polar | TM3 | T | 139 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | T | 139 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | T | 139 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | H8 | K | 303 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | K | 303 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | L | 371 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | L | 241 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM2 | M | 74 | 2x39 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM2 | M | 74 | 2x39 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM2 | M | 74 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | M | 74 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | S | 238 | 6x30 | G.H5 | L | 368 | G.H5.20 |