Structure information

P2Y1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4XNV

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE14287

PUBLICATION DATE

April 1, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BMS compound 16 [PMID:23368907] F62 1.43x43 TM1 aromatic (edge-to-face)
BMS compound 16 [PMID:23368907] F66 1.47x47 TM1 hydrophobic
BMS compound 16 [PMID:23368907] L102 2.55x55 TM2 Van der Waals
BMS compound 16 [PMID:23368907] L102 2.55x55 TM2 polar (hydrogen bond with backbone)
BMS compound 16 [PMID:23368907] T103 2.56x56 TM2 Van der Waals
BMS compound 16 [PMID:23368907] P105 2.58x58 TM2 hydrophobic
BMS compound 16 [PMID:23368907] P105 2.58x58 TM2 Van der Waals
BMS compound 16 [PMID:23368907] A106 2.59x59 TM2 hydrophobic
BMS compound 16 [PMID:23368907] A106 2.59x59 TM2 Van der Waals
BMS compound 16 [PMID:23368907] F119 23.52x52 ECL1 Van der Waals
BMS compound 16 [PMID:23368907] F119 23.52x52 ECL1 aromatic (face-to-edge)
BMS compound 16 [PMID:23368907] M123 3.24x24 TM3 Van der Waals
BMS compound 16 [PMID:23368907] M123 3.24x24 TM3 hydrophobic
BMS compound 16 [PMID:23368907] L126 3.27x27 TM3 hydrophobic
BMS compound 16 [PMID:23368907] L126 3.27x27 TM3 Van der Waals
BMS compound 16 [PMID:23368907] Q127 3.28x28 TM3 Van der Waals

Ligands

BMS compound 16 [PMID:23368907]

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Residue Diagrams

S N G L F G I I F V L I Y V A P L Y Y F 1 F N L A L A D F L Y V L T L P A L I F Y 2 C T L F L I S G Y L N V H F I F R Q L K 3 A I C I S V L V W L I V V V A I S P I L 4 Y C G L I L V L P V C F M A V T T C M S Y 5 V I I V L T V F V A S Y I P F H V M K T M 6 I P D V C S N L S A L G R T V Q Y T A 7
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ICL1 M K P W ICL1ECL1 K T D W I F ECL1ICL2 P L K S L G R L ICL2ECL2 G T G V R K N K T I T C Y D T T S D E Y ECL2ICL3 D L D N S ICL3ECL3 F Q T P A ECL3N-term M T E V L W P A V P N G T D A A F L A G P G S S W G N S T V A S T A A V S S S F K C A L T K T G N-termC-term K A S R R S E A N L Q S K S E D M T L N I L P E F K Q N G D T S L C-term F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y K K K N A I C I S V L V W L I V V V A I S P I L F Y S L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T L S R F R R R A T R
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y1 receptor
TM1
1x43 1.43x43 F62
1x47 1.47x47 F66
TM2
2x55 2.55x55 L102
2x56 2.56x56 T103
2x58 2.58x58 P105
2x59 2.59x59 A106
ECL1
23x52 23.52x52 F119
TM3
3x24 3.24x24 M123
3x27 3.27x27 L126
3x28 3.28x28 Q127