Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8JIS

SPECIES

Homo sapiens

RESOLUTION

2.460

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2303696120

PUBLICATION DATE

Nov. 8, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Dual-agonist peptide P15 V30 N-term polar (hydrogen bond with backbone)
Dual-agonist peptide P15 V30 N-term Van der Waals
Dual-agonist peptide P15 S31 N-term Van der Waals
Dual-agonist peptide P15 L32 N-term Van der Waals
Dual-agonist peptide P15 L32 N-term polar (hydrogen bond with backbone)
Dual-agonist peptide P15 V36 N-term hydrophobic
Dual-agonist peptide P15 V36 N-term Van der Waals
Dual-agonist peptide P15 W39 N-term hydrophobic
Dual-agonist peptide P15 W39 N-term Van der Waals
Dual-agonist peptide P15 Y69 N-term Van der Waals
Dual-agonist peptide P15 Y88 N-term polar (hydrogen bond)
Dual-agonist peptide P15 E138 N-term Van der Waals
Dual-agonist peptide P15 L141 1.36x36 TM1 Van der Waals
Dual-agonist peptide P15 L141 1.36x36 TM1 hydrophobic
Dual-agonist peptide P15 L144 1.39x39 TM1 hydrophobic
Dual-agonist peptide P15 Y145 1.40x40 TM1 Van der Waals
Dual-agonist peptide P15 Y148 1.43x43 TM1 Van der Waals
Dual-agonist peptide P15 Y148 1.43x43 TM1 aromatic (edge-to-face)
Dual-agonist peptide P15 Y152 1.47x47 TM1 Van der Waals
Dual-agonist peptide P15 V194 2.64x64 TM2 Van der Waals
Dual-agonist peptide P15 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 L201 2.71x71 TM2 hydrophobic
Dual-agonist peptide P15 L201 2.71x71 TM2 Van der Waals
Dual-agonist peptide P15 K202 2.72x72 TM2 Van der Waals
Dual-agonist peptide P15 Y205 2.75x75 TM2 Van der Waals
Dual-agonist peptide P15 Y205 2.75x75 TM2 hydrophobic
Dual-agonist peptide P15 W214 ECL1 aromatic (face-to-face)
Dual-agonist peptide P15 W214 ECL1 Van der Waals
Dual-agonist peptide P15 Q234 3.37x37 TM3 polar (hydrogen bond)
Dual-agonist peptide P15 V237 3.40x40 TM3 Van der Waals
Dual-agonist peptide P15 V237 3.40x40 TM3 hydrophobic
Dual-agonist peptide P15 T298 45.52x52 ECL2 Van der Waals
Dual-agonist peptide P15 T298 45.52x52 ECL2 polar (hydrogen bond)
Dual-agonist peptide P15 R299 ECL2 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 N300 ECL2 polar (hydrogen bond with backbone)
Dual-agonist peptide P15 N300 ECL2 Van der Waals
Dual-agonist peptide P15 W306 5.36x37 TM5 Van der Waals
Dual-agonist peptide P15 W306 5.36x37 TM5 hydrophobic
Dual-agonist peptide P15 E373 ECL3 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 L384 7.39x38 TM7 hydrophobic
Dual-agonist peptide P15 L384 7.39x38 TM7 Van der Waals
Dual-agonist peptide P15 E387 7.42x41 TM7 Van der Waals
Dual-agonist peptide P15 L388 7.43x42 TM7 hydrophobic
Dual-agonist peptide P15 L388 7.43x42 TM7 Van der Waals

Ligands

Dual-agonist peptide P15

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388