Ro 60-0175


SMILES C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
InChIKey XJJZQXUGLLXTHO-ZETCQYMHSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 226.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2C

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.7 7.95 8.2 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.29 8.29 8.29 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.58 8.44 8.9 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.41 7.44 7.5 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pEC50 6.7 6.7 6.7 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 8.37 8.54 8.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 7.28 8.11 8.66 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 6.4 7.1 7.57 ChEMBL