GPCRdb

BUTORPHAN

Agent/drug
Bioactivity

BUTORPHAN

SMILES	Oc1ccc2c(c1)[C@@]13CCCC[C@H]1[C@@H](C2)N(CC1CCC1)CC3
InChIKey	YSTAPDGDOHWKQR-CEWLAPEOSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	311.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	8.23	8.35	8.89	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pKi	10.10	10.13	10.15	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	10.10	10.10	10.14	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	9.64	9.66	9.92	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

κ	OPRK	Human	Opioid	A	pEC50	8.89	8.89	8.89	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	8.80	8.80	8.80	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	7.70	7.70	7.70	ChEMBL

Showing 1 to 3 of 3 entries

BUTORPHAN

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.