SB 242084


SMILES O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C
InChIKey GIUZEIJUFOPTMR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 394.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT1A 5-HT2C

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.1 6.45 6.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.8 6.9 7.0 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 9.8 9.8 9.8 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 9.0 9.0 9.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.2 8.6 9.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 9.48 9.48 9.48 ChEMBL