GPCRdb

EBASTINE

Agent/drug
Bioactivity

EBASTINE

SMILES	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1
InChIKey	MJJALKDDGIKVBE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	9
Molecular weight (Da)	469.3

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	5.98	5.98	5.98	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.63	6.63	6.63	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.06	6.06	6.06	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.51	6.51	6.51	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.47	6.47	6.47	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.40	7.40	7.40	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.72	5.72	5.72	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.85	5.85	5.85	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.59	7.59	7.59	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.70	6.70	6.70	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.91	6.91	6.91	ChEMBL

Showing 1 to 20 of 47 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.58	5.58	5.58	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.25	8.25	8.25	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.38	6.38	6.38	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.75	5.75	5.75	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.08	6.08	6.08	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.13	6.13	6.13	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.56	6.56	6.56	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.59	5.59	5.59	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	7.33	7.33	7.33	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	8.13	8.13	8.13	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.64	5.64	5.64	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.04	7.04	7.04	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.50	6.50	6.50	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.62	6.62	6.62	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.66	5.66	5.66	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	5.50	5.50	5.50	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.92	5.92	5.92	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.94	6.58	7.21	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.14	8.14	8.14	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	6.92	6.92	6.92	ChEMBL

Showing 1 to 20 of 32 entries

EBASTINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02		0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z		0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05		0.606	4	Yes

Showing 1 to 3 of 3 entries