SCH-23390


SMILES CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O
InChIKey GOTMKOSCLKVOGG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 287.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 7.4 8.45 9.5 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKd 9.5 9.5 9.5 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 7.5 8.5 9.5 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKd 9.2 9.2 9.2 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 5.62 5.97 6.32 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 8.91 8.91 8.92 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.39 8.53 9.1 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.28 6.33 6.37 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.18 6.18 6.18 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.91 7.91 7.91 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.29 7.58 7.87 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 6.42 6.42 6.42 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 7.46 7.46 7.46 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.76 7.26 7.77 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.05 6.05 6.05 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pIC50 9.25 9.25 9.25 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.13 7.99 9.51 ChEMBL