substance P


SMILES None
InChIKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Sequence RPKPQQFFGLM

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 8U26 7RMG 7RMI 7RMH 7VDM 7P00 7P02

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK1 NK1R Human Tachykinin A pKi 8.5 9.4 10.3 Guide to Pharmacology
NK1 NK1R Human Tachykinin A pKd 8.6 8.6 8.6 Guide to Pharmacology
NK2 NK2R Human Tachykinin A pKi 5.9 6.4 6.9 Guide to Pharmacology
NK3 NK3R Mouse Tachykinin A pKi 5.3 5.3 5.3 Guide to Pharmacology
NK1 NK1R Guinea pig Tachykinin A pKi 7.3 7.3 7.3 ChEMBL
NK1 NK1R Rat Tachykinin A pKi 8.96 8.96 8.96 ChEMBL
NK1 NK1R Human Tachykinin A pKi 8.8 8.8 8.8 ChEMBL
NK1 NK1R Human Tachykinin A pKi 8.55 9.66 10.38 PDSP Ki database
NK1 NK1R Guinea pig Tachykinin A pKi 9.62 9.93 10.23 PDSP Ki database
NK1 NK1R Rat Tachykinin A pKi 8.99 9.63 10.27 PDSP Ki database
NK2 NK2R Human Tachykinin A pKi 6.89 6.89 6.89 PDSP Ki database
NK3 NK3R Human Tachykinin A pKi 5.89 5.89 5.89 PDSP Ki database
NK2 NK2R Human Tachykinin A pKi 6.99 6.99 6.99 ChEMBL
NK3 NK3R Human Tachykinin A pKi 5.0 5.5 6.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MRGPRX2 MRGX2 Human A orphans A pEC50 5.97 5.97 5.97 Guide to Pharmacology
NK3 NK3R Guinea pig Tachykinin A pIC50 6.14 6.14 6.14 ChEMBL
NK2 NK2R Golden hamster Tachykinin A pIC50 6.83 6.83 6.83 ChEMBL
NK3 NK3R Rat Tachykinin A pIC50 6.89 6.89 6.89 ChEMBL
NK3 NK3R Rat Tachykinin A pEC50 5.12 5.12 5.12 ChEMBL
NK2 NK2R Rat Tachykinin A pEC50 6.78 7.52 9.0 ChEMBL
NK2 NK2R Rat Tachykinin A pIC50 6.7 6.7 6.7 ChEMBL
NK1 NK1R Guinea pig Tachykinin A pEC50 8.25 8.52 9.0 ChEMBL
NK1 NK1R Guinea pig Tachykinin A pIC50 10.15 10.15 10.15 ChEMBL
NK1 NK1R Rat Tachykinin A pIC50 8.82 9.5 9.92 ChEMBL
NK3 NK3R Human Tachykinin A pEC50 6.1 6.1 6.1 ChEMBL
NK3 NK3R Human Tachykinin A pIC50 6.9 6.9 6.9 ChEMBL
NK1 NK1R Human Tachykinin A pIC50 8.77 9.16 9.92 ChEMBL
NK1 NK1R Human Tachykinin A pEC50 9.0 9.42 10.24 ChEMBL
ghrelin GHSR Human Ghrelin A pEC50 7.18 7.18 7.18 ChEMBL
NK2 NK2R Human Tachykinin A pIC50 6.61 6.61 6.61 ChEMBL