telmisartan


SMILES CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
InChIKey RMMXLENWKUUMAY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 514.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTRA Rat Angiotensin A pKi 9.64 9.64 9.64 ChEMBL
AT1 AGTRA Rat Angiotensin A pKi 8.02 8.02 8.02 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Human Angiotensin A pIC50 8.4 8.4 8.4 Guide to Pharmacology
AT1 AGTRB Rat Angiotensin A pIC50 8.52 8.52 8.52 ChEMBL
AT2 AGTR2 Human Angiotensin A pIC50 9.48 9.48 9.48 ChEMBL
AT1 AGTR1 Human Angiotensin A pIC50 6.82 8.71 9.31 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.9 5.9 5.9 ChEMBL
AT1 AGTR1 Human Angiotensin A pIC50 8.03 8.03 8.03 Drug Central
AT2 AGTR2 Human Angiotensin A pIC50 8.02 8.02 8.02 Drug Central
AT1 AGTRB Rat Angiotensin A pIC50 8.07 8.07 8.07 Drug Central