trazodone


SMILES Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
InChIKey PHLBKPHSAVXXEF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 371.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.7 7.95 8.2 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.4 6.55 6.7 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.08 6.08 6.08 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 7.21 7.21 7.21 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.93 6.97 7.02 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.96 6.31 6.66 PDSP Ki database
α1A ADA1A Rat Adrenoceptors A pKi 7.33 7.33 7.33 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.89 6.89 6.89 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.75 6.75 6.75 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.55 6.55 6.55 ChEMBL
H1 HRH1 Human Histamine A pKi 7.38 7.38 7.38 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.65 6.7 6.75 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.47 6.47 6.47 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.17 7.17 7.17 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.33 7.33 7.33 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.93 6.93 6.93 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.72 6.98 7.13 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.7 7.87 8.22 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.7 6.27 6.71 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.38 7.38 7.38 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 7.54 7.54 7.54 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.65 6.65 6.65 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.35 7.46 7.57 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 6.82 6.82 6.82 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 6.14 6.14 6.14 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 6.81 6.81 6.81 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.43 5.43 5.43 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.38 5.42 5.46 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 6.15 6.15 6.15 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
H2 HRH2 Human Histamine A pKi 5.48 5.48 5.48 PDSP Ki database
H4 HRH4 Human Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
δ OPRD Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
μ OPRM Human Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
CB1 CNR1 Human Cannabinoid A pKi 5.0 5.0 5.0 PDSP Ki database
CB2 CNR2 Human Cannabinoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
κ OPRK Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
H3 HRH3 Guinea pig Histamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
D1 DRD1 Human Dopamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Human Dopamine A pKi 8.26 8.26 8.26 Drug Central
D4 DRD4 Human Dopamine A pKi 8.21 8.21 8.21 Drug Central
H1 HRH1 Human Histamine A pKi 8.21 8.21 8.21 Drug Central
H2 HRH2 Human Histamine A pKi 8.26 8.26 8.26 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.97 6.97 6.97 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 8.23 8.23 8.23 Drug Central
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 5.87 5.87 5.87 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 6.96 6.96 6.96 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 6.93 6.93 6.93 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.65 4.65 4.65 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 6.58 6.58 6.58 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 6.41 6.41 6.41 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 5.71 5.71 5.71 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.44 6.44 6.44 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.51 6.51 6.51 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.04 6.04 6.04 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.97 6.97 6.97 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.04 7.04 7.04 ChEMBL
D3 DRD3 Human Dopamine A pIC50 5.43 5.43 5.43 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.61 7.16 7.7 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 6.11 6.11 6.11 ChEMBL
D2 DRD2 Human Dopamine A pIC50 5.35 5.35 5.35 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.02 8.02 8.02 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pIC50 8.11 8.11 8.11 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.16 8.16 8.16 Drug Central