CLEBOPRIDE


SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1
InChIKey BVPWJMCABCPUQY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 373.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations D2

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Bovine Dopamine A pKi 5.22 5.22 5.22 ChEMBL
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 6.98 6.98 6.98 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 6.98 6.98 6.98 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.92 8.36 8.95 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.49 8.49 8.49 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.77 7.38 7.98 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.75 7.83 7.92 ChEMBL
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 7.27 7.27 7.27 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 8.89 8.89 8.89 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 6.09 6.09 6.09 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
D3 DRD3 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
D4 DRD4 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
D1 DRD1 Bovine Dopamine A pKi 8.28 8.28 8.28 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.05 8.05 8.05 Drug Central
D2 DRD2 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 7.77 7.77 7.77 ChEMBL