GPCRdb

CP-226269

Agent/drug
Bioactivity

CP-226269

SMILES	Fc1ccc2[nH]c(CN3CCN(c4ccccn4)CC3)cc2c1
InChIKey	PQOIDBZLMJMYCD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	310.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

κ	OPRK	Human	Opioid	A	pKi	6.52	6.52	6.52	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.70	6.70	6.70	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.92	6.92	6.92	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.25	6.25	6.25	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pKi	9.40	9.40	9.40	Guide to Pharmacology
D₄	DRD4	Human	Dopamine	A	pKi	8.44	8.44	8.44	ChEMBL

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pEC50	6.28	6.77	7.26	ChEMBL
D₄	DRD4	Rat	Dopamine	A	pEC50	7.44	7.55	7.66	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	7.50	7.50	7.50	ChEMBL

Showing 1 to 3 of 3 entries

CP-226269

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₄

Compound is not listed as a drug.