CHEMBL3597593


SMILES O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2ccccn2)CC1
InChIKey YFKGKOJKLVSGSA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 320.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 7.41 7.41 7.41 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 10.0 10.0 10.0 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 9.52 9.52 9.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 6.68 6.68 6.68 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 9.4 9.4 9.4 ChEMBL