CHEMBL3597598


SMILES O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2cccc(Cl)c2)CC1
InChIKey NTDNSTJWFZRSLJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 353.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 7.73 7.73 7.73 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 9.4 9.4 9.4 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 9.3 9.3 9.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 5.87 5.87 5.87 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.42 8.42 8.42 ChEMBL