GPCRdb

CHEMBL368061

Agent/drug
Bioactivity

CHEMBL368061

SMILES	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1
InChIKey	POZFPYZCVYTCQZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	381.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.30	8.47	9.30	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	9.30	9.30	9.30	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.39	5.88	6.55	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	4.92	5.37	5.69	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pKi	6.13	6.82	7.16	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.58	5.69	5.80	ChEMBL
H₁	HRH1	Rat	Histamine	A	pKi	6.85	7.04	7.24	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.84	6.98	7.82	ChEMBL

Showing 1 to 1 of 1 entry

CHEMBL368061

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.