GPCRdb

CHEMBL376355

Agent/drug
Bioactivity

CHEMBL376355

SMILES	Nc1nc2c(s1)C[C@H]1[C@H]3Cc4ccc(O)cc4[C@@]1(CCN3CC1CCC1)C2
InChIKey	LLZGBQVJBUASJT-LRXVAGHRSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	381.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	8.96	8.96	8.96	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	9.85	9.85	9.85	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	9.43	9.43	9.43	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pEC50	8.60	8.60	8.60	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	7.03	7.03	7.03	ChEMBL
κ	OPRK	Human	Opioid	A	pEC50	8.59	8.59	8.59	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	7.58	7.58	7.58	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	8.59	8.59	8.59	ChEMBL

Showing 1 to 5 of 5 entries

CHEMBL376355

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.