GPCRdb

CHEMBL378455

Agent/drug
Bioactivity

CHEMBL378455

SMILES	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1
InChIKey	UOKGFRGTMUWXQL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	315.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.43	7.43	7.43	ChEMBL
5-HT_2A	5HT2A	Pig	5-Hydroxytryptamine	A	pKi	5.68	5.68	5.68	ChEMBL
D₁	DRD1	Pig	Dopamine	A	pKi	5.52	5.52	5.52	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.42	7.48	7.55	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.48	7.48	7.48	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	9.23	9.23	9.23	ChEMBL

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pEC50	7.50	8.10	8.77	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.48	8.48	8.48	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	8.02	8.13	8.25	ChEMBL

Showing 1 to 3 of 3 entries

CHEMBL378455

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.