GPCRdb

5-OH-DPAT

Agent/drug
Bioactivity

5-OH-DPAT

SMILES	CCCN(CCC)C1CCc2c(O)cccc2C1
InChIKey	MDBWEQVKJDMEMK-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	247.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.46	6.46	6.46	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.98	5.98	5.98	ChEMBL
5-HT_1B	5HT1B	Mouse	5-Hydroxytryptamine	A	pKi	8.40	8.40	8.40	Guide to Pharmacology
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.33	6.33	6.33	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.23	7.56	8.22	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	6.82	7.68	9.15	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.36	8.82	9.18	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKi	8.68	8.81	8.87	ChEMBL

Showing 1 to 8 of 8 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pEC50	7.38	7.68	7.98	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	8.40	8.40	8.40	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.91	9.38	9.85	ChEMBL

Showing 1 to 3 of 3 entries

5-OH-DPAT

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.