ergotamine



ergotamine


SMILES O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
InChIKey XCGSFFUVFURLIX-VFGNJEKYSA-N

Chemical Properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 4
Molecular weight (Da) 581.3


Bioactivities

ergotamine


Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Clinical Trials

Phase I 9
Phase II 0
Phase III 0
Approved Yes


Sankey plot

Migraine, unspecified There is 9 stuff in this nodeMigraine, unspecifiedDiseases of the nervous system There is 9 stuff in this nodeDiseases of thenervous systemErgotamine There is 27 stuff in this nodeErgotamine5-HT<sub>1D</sub> receptor There is 3 stuff in this node5-HT1D receptor5-HT<sub>1B</sub> receptor There is 3 stuff in this node5-HT1B receptorOrthostatic hypotension There is 9 stuff in this nodeOrthostatic hypotensionDiseases of the circulatory system There is 9 stuff in this nodeDiseases of thecirculatory system&alpha;<sub>1D</sub>-adrenoceptor There is 3 stuff in this nodeα1D-adrenoceptor&alpha;<sub>1A</sub>-adrenoceptor There is 3 stuff in this nodeα1A-adrenoceptor&alpha;<sub>1B</sub>-adrenoceptor There is 3 stuff in this nodeα1B-adrenoceptor&alpha;<sub>2A</sub>-adrenoceptor There is 3 stuff in this nodeα2A-adrenoceptor&alpha;<sub>2B</sub>-adrenoceptor There is 3 stuff in this nodeα2B-adrenoceptor&alpha;<sub>2C</sub>-adrenoceptor There is 3 stuff in this nodeα2C-adrenoceptor5-HT<sub>2A</sub> receptor There is 3 stuff in this node5-HT2A receptorHeadache, not elsewhere classified There is 9 stuff in this nodeHeadache, not elsewhereclassifiedSymptoms, signs or clinical findings, not elsewhere classified There is 9 stuff in this nodeSymptoms, signs orclinical findings, notelsewhere classified


Drug Information