GPCRdb

fenoldopam

Agent/drug
Bioactivity

fenoldopam

SMILES	Oc1ccc(C2CNCCc3c2cc(O)c(O)c3Cl)cc1
InChIKey	TVURRHSHRRELCG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	1
Molecular weight (Da)	305.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem PubChem GPCRdb
Structure pdb	7X2C 8JLQ 7CKW
Ligand site mutations	D₂ D₅

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.00	5.33	5.67	PDSP Ki database
A_2B	AA2BR	Rat	Adenosine	A	pKi	7.45	7.45	7.45	ChEMBL
A_2B	AA2BR	Rat	Adenosine	A	pKi	8.13	8.13	8.13	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	6.50	6.83	7.90	Guide to Pharmacology
D₁	DRD1	Rat	Dopamine	A	pKi	8.52	8.71	8.91	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	7.40	7.40	7.40	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKd	5.74	6.64	7.55	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.74	6.64	7.55	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	8.07	8.07	8.07	Drug Central
D₁	DRD1	Human	Dopamine	A	pKd	8.12	8.12	8.12	Drug Central
D₂	DRD2	Bovine	Dopamine	A	pKi	6.10	6.10	6.10	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKd	4.89	5.52	5.89	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	7.88	7.88	7.88	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.09	6.09	6.09	ChEMBL
D₂	DRD2	Dog	Dopamine	A	pKi	8.55	8.55	8.55	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.22	8.22	8.22	Drug Central
D₂	DRD2	Rat	Dopamine	A	pKd	8.23	8.23	8.23	Drug Central
D₂	DRD2	Bovine	Dopamine	A	pKi	8.21	8.21	8.21	Drug Central
D₄	DRD4	Human	Dopamine	A	pKi	6.50	6.50	6.50	Guide to Pharmacology
D₄	DRD4	Human	Dopamine	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 20 of 23 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Rat	Dopamine	A	pEC50	7.24	7.24	7.24	ChEMBL
D₁	DRD1	Human	Dopamine	A	pEC50	7.50	8.03	8.55	ChEMBL
D₂	DRD2	Bovine	Dopamine	A	pIC50	5.80	5.80	5.80	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.20	5.20	5.20	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.57	5.57	5.57	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pIC50	5.09	5.09	5.09	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 7 of 7 entries

fenoldopam

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 2

Phase IV 4

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem PubChem Guide To Pharmacology ChEMBL_compound_ids PubChem PubChem GPCRdb
Structure pdb	7X2C 8JLQ 7CKW
Ligand site mutations	D₂ D₅

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	C01C	0.542
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Essential hypertension, unspecified	4	BA00.Z	C01C	0.466
DRD5	D₅ receptor	Dopamine receptors	Aminergic receptors	A	Diseases of the circulatory system, unspecified	4	BE2Z	C01C	0.526
DRD5	D₅ receptor	Dopamine receptors	Aminergic receptors	A	Essential hypertension, unspecified	4	BA00.Z	C01C	0.039

Showing 1 to 4 of 4 entries