GPCRdb

CHEMBL427860

Agent/drug
Bioactivity

CHEMBL427860

SMILES	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1
InChIKey	FRHBHVROLQSPMW-BTYSJIOQSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	10
Molecular weight (Da)	526.3

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

ghrelin	GHSR	Human	Ghrelin	A	pKi	6.17	6.17	6.17	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pKi	6.23	6.30	6.38	ChEMBL
MC₄	MC4R	Mouse	Melanocortin	A	pKi	8.49	8.49	8.49	ChEMBL
MC₄	MC4R	Human	Melanocortin	A	pKi	8.55	8.55	8.55	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pKi	5.92	6.20	6.47	ChEMBL

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

MC₄	MC4R	Human	Melanocortin	A	pIC50	7.46	7.46	7.46	ChEMBL

Showing 1 to 1 of 1 entry

CHEMBL427860

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.