CHEMBL452847


SMILES CN1CCN(c2nc(NCc3cccs3)c3cc(Cl)ccc3n2)CC1
InChIKey OLJSGKYQYTWQNJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 373.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pKi 7.8 7.8 7.8 ChEMBL
H4 HRH4 Human Histamine A pKi 7.37 7.87 8.12 ChEMBL
H1 HRH1 Human Histamine A pKi 6.26 6.98 7.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 7.16 7.16 7.16 ChEMBL