GPCRdb

7-OH-DPAT

Agent/drug
Bioactivity

7-OH-DPAT

SMILES	CCCN(CCC)C1CCc2ccc(O)cc2C1
InChIKey	BLYMJBIZMIGWFK-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	247.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	D₂ D₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.55	6.34	7.14	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.58	6.94	7.29	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.33	7.33	7.33	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	5.99	5.99	5.99	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.60	6.60	7.60	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pKi	6.20	6.20	6.20	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pKi	6.51	7.03	8.60	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.75	7.06	8.57	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	6.42	7.20	8.03	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.84	6.95	8.64	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.10	7.75	8.40	Guide to Pharmacology
D₃	DRD3	Human	Dopamine	A	pKd	9.60	9.60	9.60	Guide to Pharmacology
D₃	DRD3	Rat	Dopamine	A	pKd	9.10	9.10	9.10	Guide to Pharmacology
D₃	DRD3	Rat	Dopamine	A	pKi	8.21	8.47	8.93	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKd	9.17	9.17	9.17	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.57	8.35	8.85	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.25	8.55	9.41	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	8.41	8.65	8.89	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	6.83	6.83	6.83	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.82	5.82	5.82	PDSP Ki database

Showing 1 to 20 of 20 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pIC50	6.72	7.00	7.52	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	8.73	8.73	8.73	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	7.40	7.40	7.40	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	8.90	8.93	8.96	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	9.02	9.15	9.28	ChEMBL

Showing 1 to 5 of 5 entries

7-OH-DPAT

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Guide To Pharmacology PubChem GPCRdb
Ligand site mutations	D₂ D₃

Compound is not listed as a drug.