GPCRdb

CHEMBL488248

Agent/drug
Bioactivity

CHEMBL488248

SMILES	Cn1c(-c2ccc(OCCCN3CCCC3)cc2)nc2ccccc2c1=O
InChIKey	PRPSMPHMELIHFQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	363.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Mouse	Histamine	A	pKd	8.51	8.55	8.59	ChEMBL
H₃	HRH3	Mouse	Histamine	A	pKi	8.62	8.62	8.62	ChEMBL
H₃	HRH3	Rat	Histamine	A	pKi	7.92	7.92	7.92	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	8.38	9.02	9.66	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	8.38	8.38	8.38	PDSP Ki database

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	5.66	5.66	5.66	ChEMBL
H₃	HRH3	Mouse	Histamine	A	pEC50	8.02	8.02	8.02	ChEMBL
H₃	HRH3	Human	Histamine	A	pIC50	9.17	9.17	9.17	ChEMBL

Showing 1 to 3 of 3 entries

CHEMBL488248

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.