ILOPROST


SMILES CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O
InChIKey HIFJCPQKFCZDDL-ACWOEMLNSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 8
Molecular weight (Da) 360.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
IP PI2R Rat Prostanoid A pKi 9.0 9.0 9.0 ChEMBL
IP PI2R Human Prostanoid A pKi 8.14 8.27 8.49 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 5.43 5.43 5.43 ChEMBL
EP2 PE2R2 Rat Prostanoid A pKi 8.23 8.23 8.23 Drug Central
EP4 PE2R4 Mouse Prostanoid A pKi 8.25 8.25 8.25 Drug Central
IP PI2R Mouse Prostanoid A pKi 8.1 8.1 8.1 Drug Central
EP2 PE2R2 Mouse Prostanoid A pKi 8.24 8.24 8.24 Drug Central
EP2 PE2R2 Human Prostanoid A pKi 8.24 8.24 8.24 Drug Central
TP TA2R Human Prostanoid A pKi 8.28 8.28 8.28 Drug Central
DP1 PD2R Human Prostanoid A pKi 8.18 8.18 8.18 Drug Central
EP4 PE2R4 Human Prostanoid A pKi 8.18 8.18 8.18 Drug Central
FP PF2R Human Prostanoid A pKi 8.21 8.21 8.21 Drug Central
EP1 PE2R1 Mouse Prostanoid A pKi 8.11 8.11 8.11 Drug Central
EP3 PE2R3 Mouse Prostanoid A pKi 8.12 8.12 8.12 Drug Central
EP1 PE2R1 Rat Prostanoid A pKi 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
IP PI2R Rat Prostanoid A pEC50 9.16 9.16 9.16 ChEMBL
IP PI2R Human Prostanoid A pIC50 7.57 7.87 8.08 ChEMBL
IP PI2R Human Prostanoid A pEC50 8.62 9.01 9.4 ChEMBL
DP1 PD2R Human Prostanoid A pEC50 5.69 6.26 6.83 ChEMBL
EP1 PE2R1 Human Prostanoid A pEC50 9.52 9.52 9.52 ChEMBL
EP2 PE2R2 Human Prostanoid A pEC50 5.68 5.68 5.68 ChEMBL
EP1 PE2R1 Human Prostanoid A pEC50 8.11 8.11 8.11 Drug Central
EP3 PE2R3 Human Prostanoid A pEC50 8.14 8.14 8.14 Drug Central
IP PI2R Human Prostanoid A pEC50 8.11 8.11 8.11 Drug Central
EP3 PE2R3 Rat Prostanoid A pEC50 8.04 8.04 8.04 Drug Central
IP PI2R Rat Prostanoid A pEC50 8.04 8.04 8.04 Drug Central