CHEMBL494093


SMILES CN1CCN(c2nc(N)nc3c2CCc2ccccc2-3)CC1
InChIKey CEUMRIVIGREJGB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 295.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pKi 8.27 8.27 8.27 ChEMBL
H4 HRH4 Human Histamine A pKi 6.73 7.27 7.81 ChEMBL
H2 HRH2 Human Histamine A pKi 4.5 4.5 4.5 ChEMBL
H1 HRH1 Human Histamine A pKi 5.04 5.04 5.04 ChEMBL
H3 HRH3 Human Histamine A pKi 5.01 5.01 5.01 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pEC50 7.81 7.81 7.81 ChEMBL
H4 HRH4 Human Histamine A pEC50 6.53 6.53 6.53 ChEMBL