GPCRdb

PAROXETINE

Agent/drug
Bioactivity

PAROXETINE

SMILES	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1
InChIKey	AHOUBRCZNHFOSL-YOEHRIQHSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	329.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	4.50	4.51	4.52	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	8.34	8.34	8.34	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.31	5.31	5.31	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.00	5.01	5.04	PDSP Ki database
5-HT_2C	A0A4W2GLI9	Hybrid cattle	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.27	8.27	8.27	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 36 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.40	5.65	5.90	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.84	6.84	6.84	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	6.27	6.27	6.27	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.75	6.75	6.75	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.61	6.61	6.61	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.91	6.91	6.91	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pIC50	6.05	6.05	6.05	ChEMBL
NK₁	NK1R	Human	Tachykinin	A	pIC50	8.22	8.22	8.22	Drug Central

Showing 1 to 8 of 8 entries

PAROXETINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.