GPCRdb

GSK1331258

Agent/drug
Bioactivity

GSK1331258

SMILES	Cn1c(CN2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)nc2ccccc21
InChIKey	BQOUGDGGUWVLTD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	409.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Human	Dopamine	A	pKi	5.30	5.30	5.30	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.30	5.30	5.30	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	6.20	6.20	6.20	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	7.10	7.10	7.10	Guide to Pharmacology
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	5.70	6.40	7.10	ChEMBL

Showing 1 to 2 of 2 entries

GSK1331258

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.