GPCRdb

CHEMBL492884

Agent/drug
Bioactivity

CHEMBL492884

SMILES	CN1CCN(c2cc(-c3ccccc3)nc(N)n2)CC1
InChIKey	NIJGWJIOMPHDBP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	269.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	H₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₄	HRH4	Rat	Histamine	A	pKi	7.85	7.85	7.85	ChEMBL
H₄	HRH4	Human	Histamine	A	pKi	7.20	7.97	8.30	ChEMBL

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₄	HRH4	Rat	Histamine	A	pEC50	7.40	7.40	7.40	ChEMBL

Showing 1 to 1 of 1 entry

CHEMBL492884

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	H₄

Compound is not listed as a drug.