CHEMBL4802733


SMILES N[C@@]1(C(=O)O)[C@H](CSc2ccc(F)c(F)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O
InChIKey PVCLSZDVATUGHR-XJDZXMJWSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 5
Molecular weight (Da) 359.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.6 8.6 8.6 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.28 8.28 8.28 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 5.75 5.75 5.75 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pIC50 5.4 5.4 5.4 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 8.21 8.41 8.6 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.79 8.09 8.39 ChEMBL