(-)-U-50488


SMILES CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@H]1CCCC[C@@H]1N1CCCC1
InChIKey VQLPLYSROCPWFF-ROUUACIJSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 368.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Rat Opioid A pKi 9.44 9.44 9.44 ChEMBL
κ OPRK Guinea pig Opioid A pKi 7.36 8.72 9.47 ChEMBL
μ OPRM Rat Opioid A pKi 5.86 5.86 5.86 ChEMBL
κ OPRK Human Opioid A pKi 6.47 7.39 8.21 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pEC50 7.77 7.77 7.77 ChEMBL
κ OPRK Human Opioid A pEC50 7.34 8.05 9.4 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.97 5.3 ChEMBL