GPCRdb

indomethacin

Agent/drug
Bioactivity

indomethacin

SMILES	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
InChIKey	CGIGDMFJXJATDK-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	357.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

DP₂	PD2R2	Human	Prostanoid	A	pKi	6.10	6.90	7.70	Guide to Pharmacology
DP₂	PD2R2	Mouse	Prostanoid	A	pKi	5.70	5.85	6.00	Guide to Pharmacology
DP₂	PD2R2	Human	Prostanoid	A	pKi	8.19	8.19	8.19	Drug Central
DP₂	PD2R2	Mouse	Prostanoid	A	pKi	8.22	8.22	8.22	Drug Central
DP₂	PD2R2	Human	Prostanoid	A	pKi	5.10	6.20	7.30	ChEMBL
EP₂	PE2R2	Dog	Prostanoid	A	pKi	6.52	6.52	6.52	PDSP Ki database
EP₂	PE2R2	Rat	Prostanoid	A	pKi	6.52	7.13	7.74	PDSP Ki database
EP₂	PE2R2	Human	Prostanoid	A	pKi	8.11	8.11	8.11	Drug Central
EP₄	PE2R4	Human	Prostanoid	A	pKi	7.00	7.61	8.15	PDSP Ki database

Showing 1 to 9 of 9 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

DP₂	PD2R2	Human	Prostanoid	A	pEC50	6.41	6.41	6.41	ChEMBL
GPR17	GPR17	Human	A orphans	A	pIC50	4.54	4.54	4.54	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.80	5.80	5.80	ChEMBL

Showing 1 to 3 of 3 entries

indomethacin

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.