GPCRdb

SCH-23390

Agent/drug
Bioactivity

SCH-23390

SMILES	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1
InChIKey	GOTMKOSCLKVOGG-OAHLLOKOSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	287.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₅

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.58	6.58	6.58	PDSP Ki database
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	6.47	6.47	6.47	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.40	5.43	5.50	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.88	7.88	7.88	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	7.08	7.08	7.08	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.90	7.90	7.90	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.27	7.86	8.30	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.87	7.87	7.87	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.39	7.39	7.39	PDSP Ki database
5-HT₆	5HT6R	Mouse	5-Hydroxytryptamine	A	pKi	5.60	5.60	5.60	PDSP Ki database
D₁	DRD1	Mouse	Dopamine	A	pKi	9.40	9.40	9.40	ChEMBL
D₁	DRD1	Goldfish	Dopamine	A	pKi	8.89	8.89	8.89	ChEMBL
D₁	DRD1	Pig	Dopamine	A	pKi	9.30	9.30	9.30	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	7.43	8.75	10.00	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pKi	6.17	9.19	9.92	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	7.62	9.38	10.00	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKd	9.42	9.42	9.42	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	5.00	7.12	9.24	PDSP Ki database

Showing 1 to 20 of 37 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.34	5.34	5.34	ChEMBL
apelin	APJ	Human	Apelin	A	pEC50	5.18	5.18	5.18	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pEC50	5.42	5.42	5.42	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	8.37	8.90	9.24	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.28	8.52	9.66	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.72	5.97	6.22	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.69	6.93	7.59	ChEMBL
D₅	DRD5	Human	Dopamine	A	pIC50	8.96	9.40	9.82	ChEMBL
FFA4	FFAR4	Human	Free fatty acid	A	pEC50	5.31	5.31	5.31	ChEMBL
GLP-1	GLP1R	Human	Glucagon	B1	pEC50	5.29	5.29	5.29	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pEC50	5.22	5.22	5.22	ChEMBL
GPR183	GP183	Human	A orphans	A	pEC50	5.31	5.31	5.31	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.60	4.60	4.60	ChEMBL

Showing 1 to 13 of 13 entries

SCH-23390

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₅

Compound is not listed as a drug.