GPCRdb

CLOROTEPINE

Agent/drug
Bioactivity

CLOROTEPINE

SMILES	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1
InChIKey	XRYLGRGAWQSVQW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	1
Molecular weight (Da)	344.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	9.18	9.18	9.18	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	9.25	9.25	9.25	ChEMBL
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	8.03	8.03	8.03	Drug Central
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	9.24	9.24	9.24	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.59	8.66	8.74	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.06	8.06	8.06	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	7.75	8.57	9.39	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.89	9.16	9.42	PDSP Ki database
5-HT₇	5HT7R	Guinea pig	5-Hydroxytryptamine	A	pKi	7.49	8.04	8.60	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	8.64	8.64	8.64	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pKi	8.64	8.64	8.64	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	8.06	8.06	8.06	Drug Central
D₂	DRD2	Rat	Dopamine	A	pKi	9.30	9.30	9.30	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	9.17	9.17	9.17	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	7.90	8.67	9.30	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	9.15	9.43	9.70	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.04	8.04	8.04	Drug Central

Showing 1 to 20 of 33 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Rat	Dopamine	A	pIC50	8.66	8.66	8.66	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	8.62	8.62	8.62	ChEMBL

Showing 1 to 2 of 2 entries

CLOROTEPINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.