GPCRdb

VERAPAMIL

Agent/drug
Bioactivity

VERAPAMIL

SMILES	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
InChIKey	SGTNSNPWRIOYBX-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	0
Rotatable bonds	13
Molecular weight (Da)	454.3

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.07	6.07	6.07	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.03	6.03	6.03	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.66	6.66	6.66	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.85	6.85	6.85	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.98	6.98	6.98	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.81	6.81	6.81	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	7.20	7.20	7.20	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.14	8.14	8.14	Drug Central
H₂	HRH2	Human	Histamine	A	pKi	5.59	5.59	5.59	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	8.25	8.25	8.25	Drug Central

Showing 1 to 19 of 19 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	5.68	5.68	5.68	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.25	8.25	8.25	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.77	5.77	5.77	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.24	6.24	6.24	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.52	5.52	5.52	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.26	8.26	8.26	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.36	6.36	6.36	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.78	6.78	6.78	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.53	6.53	6.53	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.73	6.73	6.73	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	5.59	5.59	5.59	ChEMBL
M₂	ACM2	Pig	Acetylcholine (muscarinic)	A	pEC50	4.51	4.51	4.51	ChEMBL
M₂	ACM2	Pig	Acetylcholine (muscarinic)	A	pEC50	8.35	8.35	8.35	Drug Central
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.30	5.30	5.30	ChEMBL

Showing 1 to 15 of 15 entries

VERAPAMIL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.