GPCRdb

CIGLITAZONE

Agent/drug
Bioactivity

CIGLITAZONE

SMILES	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1
InChIKey	YZFWTZACSRHJQD-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	333.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.21	5.21	5.21	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.22	5.22	5.22	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	4.87	4.87	4.87	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	5.02	5.02	5.02	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	5.76	5.76	5.76	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.04	5.04	5.04	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.12	5.12	5.12	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.50	5.50	5.50	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.64	5.64	5.64	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pKi	4.57	4.57	4.57	ChEMBL
NK₂	NK2R	Human	Tachykinin	A	pKi	5.38	5.38	5.38	ChEMBL

Showing 1 to 12 of 12 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	4.78	4.78	4.78	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	4.88	4.88	4.88	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	4.75	4.75	4.75	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	4.57	4.57	4.57	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	5.52	5.52	5.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	4.70	4.70	4.70	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	4.57	4.57	4.57	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	4.68	4.68	4.68	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	4.83	4.83	4.83	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	4.79	4.79	4.79	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pIC50	4.54	4.54	4.54	ChEMBL
NK₂	NK2R	Human	Tachykinin	A	pIC50	4.90	4.90	4.90	ChEMBL

Showing 1 to 12 of 12 entries

CIGLITAZONE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.