GPCRdb

PRECLAMOL

Agent/drug
Bioactivity

PRECLAMOL

SMILES	CCCN1CCC[C@@H](c2cccc(O)c2)C1
InChIKey	HTSNFXAICLXZMA-CYBMUJFWSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	219.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.38	5.57	5.76	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.10	5.10	5.10	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.50	5.50	5.50	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
CB₁	CNR1	Rat	Cannabinoid	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	4.92	6.04	7.28	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	6.15	6.97	7.67	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.64	7.34	8.07	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.64	6.55	7.76	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	6.88	7.24	7.60	ChEMBL

Showing 1 to 20 of 30 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pIC50	5.47	6.33	7.26	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pEC50	7.72	7.72	7.72	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	6.07	6.43	6.79	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	7.29	7.65	8.01	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	7.22	7.22	7.22	ChEMBL

Showing 1 to 5 of 5 entries

PRECLAMOL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₃

Compound is not listed as a drug.