GPCRdb

ECONAZOLE

Agent/drug
Bioactivity

ECONAZOLE

SMILES	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
InChIKey	LEZWWPYKPKIXLL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	380.0

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	5.07	5.07	5.07	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.36	5.36	5.36	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.79	5.79	5.79	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.57	5.57	5.57	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.25	8.25	8.25	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.13	5.13	5.13	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.34	5.34	5.34	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
δ	OPRD	Human	Opioid	A	pKi	6.29	6.29	6.29	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	8.20	8.20	8.20	Drug Central
κ	OPRK	Human	Opioid	A	pKi	5.46	5.46	5.46	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.26	8.26	8.26	Drug Central
μ	OPRM	Human	Opioid	A	pKi	5.64	5.64	5.64	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.25	8.25	8.25	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.03	5.03	5.03	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	ChEMBL

Showing 1 to 20 of 65 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	4.67	4.67	4.67	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.33	8.33	8.33	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.05	5.05	5.05	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.36	5.36	5.36	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.23	5.23	5.23	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	4.89	4.89	4.89	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.21	5.21	5.21	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	5.84	5.84	5.84	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.07	5.07	5.07	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.25	5.25	5.25	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	4.79	4.79	4.79	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.32	8.32	8.32	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	4.66	4.66	4.66	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.39	5.39	5.39	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.17	5.17	5.17	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	4.92	4.92	4.92	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	4.96	4.96	4.96	ChEMBL
A₁	AA1R	Human	Adenosine	A	pIC50	4.77	4.77	4.77	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	4.83	4.83	4.83	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	5.49	5.49	5.49	ChEMBL

Showing 1 to 20 of 38 entries

ECONAZOLE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.