GPCRdb

TICLOPIDINE

Agent/drug
Bioactivity

TICLOPIDINE

SMILES	Clc1ccccc1CN1CCc2sccc2C1
InChIKey	PHWBOXQYWZNQIN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	2
Molecular weight (Da)	263.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.84	6.84	6.84	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.86	6.86	6.86	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.77	6.77	6.77	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.42	6.42	6.42	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.52	6.52	6.52	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.93	5.93	5.93	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.60	4.60	4.60	ChEMBL

Showing 1 to 5 of 5 entries

TICLOPIDINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 2

Approved Yes

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Diseases of arteries or arterioles, unspecified	BD5Z		0.483	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z		0.441	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Other specified diseases of veins	BD7Y		0.553	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20		0.598	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Thrombophilia, unspecified	3B61.Z		0.406	4	Yes

Showing 1 to 5 of 5 entries