SCH-23390


SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1
InChIKey GOTMKOSCLKVOGG-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 287.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2 D5

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Mouse Dopamine A pKi 9.4 9.4 9.4 ChEMBL
D1 DRD1 Goldfish Dopamine A pKi 8.89 8.89 8.89 ChEMBL
D2 DRD2 Mouse Dopamine A pKi 5.92 5.92 5.92 ChEMBL
D1 DRD1 Pig Dopamine A pKi 9.3 9.3 9.3 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 7.43 8.75 10.0 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.9 7.9 7.9 ChEMBL
D5 DRD5 Human Dopamine A pKi 8.09 9.05 9.77 ChEMBL
D1 DRD1 Rat Dopamine A pKi 6.17 9.19 9.92 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 5.0 7.12 9.24 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.05 6.52 9.27 ChEMBL
D1 DRD1 Human Dopamine A pKd 9.42 9.42 9.42 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.62 9.38 10.0 ChEMBL
D5 DRD5 Rat Dopamine A pKi 9.0 9.16 9.33 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.75 9.3 9.92 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.0 6.03 6.05 ChEMBL
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 6.47 6.47 6.47 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.27 7.86 8.3 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.4 5.43 5.5 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.7 7.96 8.07 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.87 7.87 7.87 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 9.52 9.52 9.52 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 9.46 9.46 9.46 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.25 5.72 6.44 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.67 5.86 6.04 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.45 5.45 5.45 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 9.85 9.85 9.85 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 6.05 6.05 6.05 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.39 7.39 7.39 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.0 7.0 7.0 PDSP Ki database
D1 DRD1 Rhesus macaque Dopamine A pKi 8.89 9.05 9.22 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.88 7.88 7.88 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pIC50 8.96 9.4 9.82 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 8.37 8.9 9.24 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.72 5.97 6.22 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.28 8.57 9.66 ChEMBL
D2 DRD2 Human Dopamine A pIC50 5.69 6.93 7.59 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.6 4.6 4.6 ChEMBL