GPCRdb

AMILORIDE

Agent/drug
Bioactivity

AMILORIDE

SMILES	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N
InChIKey	XSDQTOBWRPYKKA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	5
Rotatable bonds	1
Molecular weight (Da)	229.0

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	A_2A A₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A₁	AA1R	Bovine	Adenosine	A	pKi	5.70	5.70	5.70	PDSP Ki database
A₁	AA1R	Rat	Adenosine	A	pKi	5.00	5.00	5.00	PDSP Ki database
A_2A	AA2AR	Human	Adenosine	A	pKi	4.92	5.11	5.48	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	8.26	8.26	8.26	Drug Central
CCK₂	GASR	Rat	Cholecystokinin	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	pKi	5.00	5.00	5.00	PDSP Ki database
M₂	ACM2	Rat	Acetylcholine (muscarinic)	A	pKi	5.00	5.00	5.00	PDSP Ki database
M₃	ACM3	Rat	Acetylcholine (muscarinic)	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 18 of 18 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 1 of 1 entry

AMILORIDE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	A_2A A₃

Compound is not listed as a drug.