MEQUITAZINE


SMILES c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2
InChIKey HOKDBMAJZXIPGC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 322.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.24 8.24 8.24 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.25 8.25 8.25 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.85 7.85 7.85 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.28 8.28 8.28 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.95 7.95 7.95 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.96 7.96 7.96 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.08 8.08 8.08 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.08 8.08 8.08 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.1 8.1 8.1 Drug Central
H1 HRH1 Human Histamine A pKi 8.08 8.08 8.08 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL