PERHEXILINE


SMILES C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1
InChIKey CYXKNKQEMFBLER-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 277.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.11 6.11 6.11 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.3 6.3 6.3 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.18 6.18 6.18 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.18 6.18 6.18 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR55 GPR55 Human GPR18, GPR55 and GPR119 A pIC50 5.5 5.5 5.5 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 5.96 5.96 5.96 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.45 5.45 5.45 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 5.51 5.51 5.51 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.57 5.57 5.57 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL