Lofepramine


SMILES CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 418.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.34 5.34 5.34 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.7 5.7 5.7 PDSP Ki database
H1 HRH1 Human Histamine A pKi 6.44 6.44 6.44 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 6.0 6.0 6.0 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.3 6.3 6.3 PDSP Ki database
β2 ADRB2 Rat Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.17 7.17 7.17 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.48 6.48 6.48 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.89 6.89 6.89 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.47 6.47 6.47 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.34 6.34 6.34 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.16 8.16 8.16 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
D2 DRD2 Human Dopamine A pKi 8.24 8.24 8.24 Drug Central
H1 HRH1 Human Histamine A pKi 8.19 8.19 8.19 Drug Central
D2 DRD2 Rat Dopamine A pKi 5.17 5.17 5.17 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database