L-161,982 (EP4A)


SMILES CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F
InChIKey JYZLVNVGBRFRME-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 654.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pKi 7.6 8.05 8.5 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 7.5 7.5 7.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Rabbit Angiotensin A pIC50 9.19 9.19 9.19 ChEMBL
AT2 AGTR2 Rat Angiotensin A pIC50 6.72 6.72 6.72 ChEMBL