BENZTROPINE


SMILES CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4
InChIKey GIJXKZJWITVLHI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 307.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.96 9.05 9.15 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.96 9.01 9.05 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.55 8.55 8.55 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.77 7.77 7.77 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 9.64 9.64 9.64 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.85 8.85 8.85 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.96 8.96 8.96 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 6.64 6.64 6.64 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.42 8.42 8.42 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 9.6 9.6 9.6 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 9.15 9.15 9.15 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 8.89 8.89 8.89 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 7.97 7.97 7.97 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 8.68 8.68 8.68 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database