Cabergoline


SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
InChIKey KORNTPPJEAJQIU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 451.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 9.02 9.12 9.21 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 9.1 9.1 9.1 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 7.22 7.22 7.22 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 6.54 6.66 6.78 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.67 6.67 6.67 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.25 7.25 7.25 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 7.65 7.65 7.65 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.7 7.7 7.7 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.92 7.92 7.92 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 7.14 7.14 7.14 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.65 7.65 7.65 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.32 6.32 6.32 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.93 8.93 8.93 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.16 6.16 6.16 PDSP Ki database
H1 HRH1 Guinea pig Histamine A pKi 5.86 5.86 5.86 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.06 8.06 8.06 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database