GPCRdb

lasmiditan

Agent/drug
Bioactivity

lasmiditan

SMILES	CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1
InChIKey	XEDHVZKDSYZQBF-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	377.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	7EXD
Ligand site mutations	5-HT_1F

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

κ	OPRK	Human	Opioid	A	pKi	6.45	6.45	6.45	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.06	6.06	6.06	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	ChEMBL
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.70	8.70	8.70	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.66	8.66	8.66	ChEMBL
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.06	8.06	8.06	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.27	5.27	5.27	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	6.60	6.60	6.60	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	6.20	6.20	6.20	ChEMBL

Showing 1 to 9 of 9 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pIC50	7.06	7.06	7.06	ChEMBL

Showing 1 to 1 of 1 entry

lasmiditan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Structure pdb	7EXD
Ligand site mutations	5-HT_1F

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N02C	0.599	4	Yes

Showing 1 to 1 of 1 entry